Til reasonable til sterke smerter som ikke lindres av enklere midler. Ofte ved postoperativ smerte, akutte skader, nervesmerter eller kroniske smerter – helst kortvarig og under tett oppfølging. En ny omfattende meta-analyse viser at legemiddelet gir så liten smertelindring at det ikke er klinisk signifikant – altså mer eller mindre ubruk

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